hyperprolactinemia and cyp2d6, drd2 and htr2c genes polymorphism in patients with schizophrenia
نویسندگان
چکیده
introduction: hyperprolactinemia is a common serious side effect of antipsychotic medications that are currently used in the treatment of patients with schizophrenia. pharmacogenetic approaches offer the possibility of identifying patient-specific biomarkers for predicting the risk of this side effect. we investigated a possible relationship between variants (snps) in genes for cytochrome 2d6 (cyp2d6), dopamine-2 receptor (drd2) and serotonin-2c receptor (htr2c) and antipsychotic drug-induced hyperprolactinemia in patients with schizophrenia. methods: overall, 128 russian patients with paranoid schizophrenia (61f/67m, aged 18-65 y) were included. serum prolactin concentration was measured with elisa. dna analysis and genotyping of cyp2d6 (rs3892097), drd2 (rs6275) and htr2c (rs6318) genes was done with steponeplus real-time pcr system using taqman® snp genotyping assays (applied biosystems, usa). results: our study showed an association of the cyp2d6 (rs3892097) and htr2c (rs6318) gene polymorphism with hyperprolactinemia in patients with schizophrenia on the background of therapy. no associations were identified between the drd2 (rs6275) gene polymorphism and the risk of antipsychotic-induced hyperprolactinemia in patients with schizophrenia. conclusion: our study confirms a contribution of genetic factors to the antipsychotic-induced hyperprolactinemia in patients with schizophrenia. further studies are required to unravel the genetic predictors of antipsychotic-induced side effects and to develop the personalized treatment strategies for patients with schizophrenia.
منابع مشابه
Hyperprolactinemia and CYP2D6, DRD2 and HTR2C genes polymorphism in patients with schizophrenia
Introduction: Hyperprolactinemia is a common serious side effect of antipsychotic medications that are currently used in the treatment of patients with schizophrenia. Pharmacogenetic approaches offer the possibility of identifying patient-specific biomarkers for predicting the risk of this side effect. We investigated a possible relationship between variants (SNPs) in genes for cytochrome 2D6 (...
متن کاملthe past hospitalization and its association with suicide attempts and ideation in patients with mdd and comparison with bmd (depressed type) group
چکیده ندارد.
Study of the association between DRD2 Gene Ser311Cys and GSTM1 Gene polymorphism in Schizophrenia
Introduction: Schizophrenia is a mental disorder affecting 1% of the world's population. Two of genes have been recognized to be involved in development of this disease: DRD2 and GSTM1. Methods: This case-control study included 100 patients suffering from schizophrenia who referred to Yazd Neuropsychiatry Hospital. Also, 100 healthy patients without schizophrenia were selected as the control g...
متن کاملAssociation between the DRD2-141C Insertion/Deletion polymorphism and schizophrenia.
Epidemiological studies have demonstrated that the genetic component is an important risk factor for the development of schizophrenia. The genes that codify the different compounds of the dopaminergic system have created interest for molecular investigations in patients with schizophrenia because the antipsychotic drugs, especially those of first generation, act on this cerebral system. Thus th...
متن کاملAssociation of CXCL12 and CXCR4 Genes Polymorphism with Proliferative Diabetic Retinopathy in Diabetic Patients
Introduction: Patients with diabetes are prone to develop complications related to the retina. So far, several genes have been reported in connection with the progression of retinopathy, and a group of these genes is genes involved in angiogenesis. CXCL12 and CXCR4 genes are among the most important genes in this path, which have been less studied and investigated. The aim of this study was to ...
متن کاملLinkage and association of DRD2 gene TaqI polymorphism with schizophrenia in an Iranian population.
BACKGROUND D2 dopamine receptor gene has been reported to be one of the most relevant candidate genes in schizophrenia. In this study, we investigated the association between TaqIA and TaqIB dopamine D2 receptor polymorphisms and psychopathology of schizophrenia. METHODS The study subjects were 38 acutely exacerbated schizophrenic patients who were all Iranian descent. The control population ...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
physiology and pharmacologyجلد ۲۱، شماره ۱، صفحات ۲۵-۳۳
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023